Statin Use Way Up: Pitavastatin Introduced to the U.S as a Next-Generation Statin - CanadaDrugstore

Statin Use Way Up: Pitavastatin Introduced to the U.S as a Next-Generation Statin

Your doctor may have recommended that you take a medication called a statin if you have high cholesterol and you haven’t been able to get it under control with diet, exercise, or weight loss alone.

Statins remain the first-line of defence for managing cholesterol. They are generally well-tolerated and have a favorable safety profile. There is a large body of evidence that supports the wide-spread use of statins with their ability to reduce the risk of developing heart disease*.

Updated Guidelines Recommend Statins for More Patients

The guidelines by the American Heart Association and American College of Cardiology updated their recommendations for managing cholesterol in 2018. The four main categories where statin use is recommended includes:

History of Statins

The first statin, lovastatin, was approved in the United States over 30 years ago on September 1st, 1987. Since then, tens of millions of Americans have taken a statin to help manage their cholesterol levels. Statin use has increased steadily over the years and has more then doubled in the last 20 years. With the recent changes to the guidelines, this use will undoubtedly increase further.

The most commonly used statin in the U.S right now is atorvastatin, which was approved in 1996. While the majority of statins currently available are several decades old, there are newer statin options available.  Pitavastatin was introduced to the U.S. in 2009 and is the most recently approved statin type.

About Pitavastatin

Pitavastatin is a third-generation statin that helps to lower the LDL-C levels in your body. It is currently available in the U.S. as Livalo (pitavastatin calcium) or Zypitamag (pitavastatin magnesium). Livalo was approved in 2009 and Zypitamag was approved in 2017.

The biggest difference between Livalo and Zypitamag is the price. Livalo costs over $1000 for a 90-day prescription, whereas Zypitamag is as little as just $1 a day, or $90 for a 90-day prescription.

Beside the price, the FDA has deemed the two products to be bioequivalent.

What makes Pitavastatin different

Click here to learn more about how Zypitamag (pitavastatin) is different.


* The effect of pitavastatin on cardiovascular morbidity and mortality has not been determined.

This article contains information about an FDA-approved product, Zypitamag (pitavastatin) tablets. This medication is available by prescription only. Talk to your doctor to see if Zypitamag is right for you. Please refer to the Zypitamag (pitavastatin) tablets Important Safety Information below and Prescribing Information for more information.




Who should NOT take ZYPITAMAG?

ZYPITAMAG is not right for everyone. Do not take ZYPITAMAG if:


What is the most important information I should know and talk to my doctor about?


What are the most common side effects of ZYPITAMAG?

The most common side effects of ZYPITAMAG in clinical studies were:


This is not a complete list of side effects. Talk to your healthcare provider for more information.


You are encouraged to report negative side effects of all drugs to the FDA. Visit or call 1-800-FDA-1088.


How should I store and take ZYPITAMAG?


Other important information I should know about ZYPITAMAG.


For additional information, please see the full Prescribing Information.

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