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What difference between Uceris(extended-release budesonide) and Entocort EC(controlled ileal-release budesonide)?

Budesonide is an anti-inflammatory drug (corticosteroid hormone). It works by decreasing the body’s natural defense response (immune response).

This medication is used to treat certain bowel conditions such as Crohn’s disease and ulcerative colitis.  While budesonide does not cure these conditions, it may decrease symptoms such as inflammation, pain, and diarrhea.

Uceris and Ortikos (both brand names in U.S) and Cortiment (brand name in Canada) contains budesonide 9mg in extended release forms.  Similarly, Entocort EC contain budesonide but it’s a 3mg strength.  Entocort EC is not interchangeable with Uceris, Ortikos, or Cortiment.

All of these medications work locally in the GI tract to reduce systemic steroid effects but they target different areas.

Uceris , Ortikos, and Cortiment target the entire colon for Ulcerative colitis

Uceris , Ortikos,and Entocort EC 

Uceris  , Ortikos, and Cortiment are indicated for the induction of remission in patients with active, mild to moderate Ulcerative colitis.

Ulcerative colitis typically begins in the rectum and may extend continuously to involve the entire colon.

These two medications provide once-daily delivery of budesonide throughout the full length of the colon with extended release for the full 24-hour period via MMX technology

Target:
Full length of colon

MMX technology:
Pill dissolves at pH ≥7.0, the approximate pH level near the entry to the colon

Dosage:
9mg tablet once daily

Entocort EC  targets the ileum and right colon for Crohn’s disease

Entocort EC

Entocort EC is indicated for the treatment of active, mild to moderate Crohn’s disease involving the ileum and/or ascending colon.

Cohn’s disease most commonly involves the end of the small intestine and beginning of the colon and may affect any part of the GI tract in a patchy pattern.

Target:

Ileum/ascending colon

Controlled ileal release:
Pill dissolve at PH>5.5 the approximate pH level of the duodenum

Dosage:
3mg x 3 capsules QD (total 9mg)

Controlled ileal-release budesonide capsules dissolve once the intestinal pH approaches 5.5, so the drug has been released by the time it reaches the general area of the hepatic flexure.

Therefore, controlled ileal-release budesonide should not be used in patients with any form of Ulcerative Colitis, including mild to moderate colitis.

Reference:

webmd.com

jamanetwork.com

ncbi.nlm.nih.gov

Seasonal Affective Disorder (SAD)

We often hear people saying they are craving the sun, or feeling depressed due to the short days and long winters.  What you may not realize is that there may be an actual reason for these feelings.  Known as Seasonal Affective Disorder or “SAD” this common ailment is often seen in people who live in regions where there are long winters and in shift workers who have less frequent exposure to natural sunlight.  The lack of sunlight can lead to feelings of depression, fatigue, anxiety, apathy, sexual problems, overeating and sleep problems.

While a quick vacation to a sunny location may provide some quick relief, this is not always financially feasible for most people and may not last for the long run.   According to Mental Health America, about five percent of Americans experience seasonal affective disorder caused by reduced sunlight in the late autumn and winter.  Four out of five people suffering from SAD are women.

One cause of SAD is thought to be Melatonin, a sleep hormone produced by the pineal gland in the brain. When the days are darker and shorter in the winter, the pineal gland produces more Melatonin, which affects sleep patterns and our moods.  Another theory states that SAD may be due to an imbalance of neurotransmitters, including serotonin, which act as mood regulators.

Phototherapy, also known as bright light therapy, is often used to help treat SAD by suppressing the body’s production of Melatonin.

Another popular therapy is the use of Vitamin D. Vitamin D., also known as the Sunshine vitamin, is reported to help individuals sleep better as it helps regulate the body’s circadian rhythm.

According to an article in Medical News Today, “Vitamin D deficiency has been linked to increased risk of asthma, cancer and chronic pain, among other conditions. Now, a new study led by researchers from the University of Georgia associates low vitamin D levels with greater risk of seasonal affective disorder.” Researchers at Queensland University of Technology in Australia state that studies found that depressed people often have lower levels of Vitamin D.

The Vitamin D Society, a Canadian non-profit group, suggests everyone have their Vitamin D levels checked, and suggests an optimal blood level of between 100-150 nmol/L.  For some this may mean daily supplementation of 4,000 IU for adults.

While it’s true that Vitamin D may not be the cure-all for Seasonal Affective Disorder, the evidence is clear that it Vitamin D does play an important role in our everyday health.

Maintaining a health Vitamin D level is important for several other reasons, including the maintenance of healthy bones and teeth, supporting lung and cardiovascular health, supporting a healthy nervous system and immune system, and even helping to regulate insulin levels for better diabetes management.

Looking to boost your Vitamin D intake?  Fish oil and fatty fish are some of the best sources of Vitamin D. One tablespoon of cod liver oil has 1,360 IU, for example.  For those who do not eat fish, 1 cup of raw maitake mushrooms packs an impressive 786 IU of Vitamin D.

Further information on Vitamin D  can be found at the following link: Learn More

Here at Jason’s CanadaDrugstore.com we offer top brand Vitamin D supplements to suit your needs. Give us a call at 1-800-991-0282 to talk to one of our team about your Vitamin D needs.

A Friendly Health Advisory:  As always, consult with your physician before taking natural supplements, vitamins and herbal supplements as they may have interactions with prescription medications you are currently taking.

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